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GSK690693

Synonyms

SourcesNames Used
GDSC1000GSK690693
PharmacoGx GSK690693

External IDs

DatabaseIdentifier
Smiles: CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
Inchikey: KGPGFQWBCSZGEL-ZDUSSCGKSA-N
Pubchem: 16725726

Annotated Targets

AKT2, PRKACB, AKT1, AKT3, PAK4, PAK6, PRKCQ, PRKG1, PRKX

Cell lines tested with GSK690693

980 cell lines have been tested with this compound, using data from 1 dataset(s).
GDM-1 haematopoietic and lymphoid tissue GDSC10001
NCI-H2087 lung GDSC10001
MDA-MB-453 breast GDSC10001
PFSK-1 central nervous system GDSC10001
MDA-MB-468 breast GDSC10001
KMH-2 thyroid GDSC10001
MOLT-13 haematopoietic and lymphoid tissue GDSC10001
BFTC-905 urinary tract GDSC10001
KURAMOCHI ovary GDSC10001
KS-1 central nervous system GDSC10001
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Top molecular features associated with response to GSK690693


Feature TypeStandardized
Nominal ANOVA
mRNA TJP1 GDSC1000 AAC -0.41 1e-11
mRNA CAPN2 GDSC1000 AAC -0.34 7e-17
mRNA NCKAP1 GDSC1000 AAC -0.33 5e-08
mRNA MYOF GDSC1000 AAC -0.32 7e-14
mRNA TNFRSF12A GDSC1000 AAC -0.31 1e-11
mRNA GNG12 GDSC1000 AAC -0.3 8e-11
mRNA FAM129B GDSC1000 AAC -0.3 1e-09
mRNA AHNAK GDSC1000 AAC -0.29 1e-15
mRNA LTBR GDSC1000 AAC -0.29 4e-13
mRNA NQO1 GDSC1000 AAC -0.29 3e-12
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