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GSK690693

Synonyms

SourcesNames Used
GDSC1000GSK690693
PharmacoGx GSK690693

External IDs

DatabaseIdentifier
Smiles: CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
Inchikey: KGPGFQWBCSZGEL-ZDUSSCGKSA-N
Pubchem: 16725726

Annotated Targets

AKT2, PRKACB, AKT1, AKT3, PAK4, PAK6, PRKCQ, PRKG1, PRKX

Cell lines tested with GSK690693

980 cell lines have been tested with this compound, using data from 1 dataset(s).
HDQ-P1 breast GDSC10001
BT-474 breast GDSC10001
A427 lung GDSC10001
KMS-12-BM haematopoietic and lymphoid tissue GDSC10001
TOV-21G ovary GDSC10001
SK-N-FI autonomic ganglia GDSC10001
CMK haematopoietic and lymphoid tissue GDSC10001
PCI-38 head and neck GDSC10001
BB65-RCC kidney GDSC10001
NB69 autonomic ganglia GDSC10001
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Top molecular features associated with response to GSK690693


Feature TypeStandardized
Nominal ANOVA
mRNA CD72 GDSC1000 AAC 0.27 2e-13
mRNA NDFIP1 GDSC1000 AAC -0.23 3e-13
mRNA LTBR GDSC1000 AAC -0.29 4e-13
mRNA RMI1 GDSC1000 AAC 0.24 6e-13
mRNA CD79B GDSC1000 AAC 0.27 7e-13
mRNA NCKAP1L GDSC1000 AAC 0.37 8e-13
mRNA FNDC3B GDSC1000 AAC -0.25 9e-13
mRNA E2F2 GDSC1000 AAC 0.26 1e-12
mRNA CD1C GDSC1000 AAC 0.23 1e-12
mRNA NQO1 GDSC1000 AAC -0.29 3e-12
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