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GSK690693

Synonyms

SourcesNames Used
GDSC1000GSK690693
PharmacoGx GSK690693

External IDs

DatabaseIdentifier
Smiles: CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
Inchikey: KGPGFQWBCSZGEL-ZDUSSCGKSA-N
Pubchem: 16725726

Annotated Targets

AKT2, PRKACB, AKT1, AKT3, PAK4, PAK6, PRKCQ, PRKG1, PRKX

Cell lines tested with GSK690693

980 cell lines have been tested with this compound, using data from 1 dataset(s).
DJM-1 skin GDSC10001
VA-ES-BJ bone GDSC10001
Calu-3 lung GDSC10001
CHP-126 autonomic ganglia GDSC10001
CAL-33 upper aerodigestive tract GDSC10001
42-MG-BA central nervous system GDSC10001
NALM-6 haematopoietic and lymphoid tissue GDSC10001
HEY ovary GDSC10001
BHT-101 thyroid GDSC10001
LN-229 central nervous system GDSC10001
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Tissues tested with GSK690693

35 tissues have been tested with this compound, using data from 1 dataset(s).
neuroblastomaGDSC10001
adrenal glandGDSC10001
placentaGDSC10001
miscGDSC10001
small intestineGDSC10001
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Top molecular features associated with response to GSK690693


Feature TypeStandardized
Nominal ANOVA
mRNA SNX22 GDSC1000 AAC 0.3 9e-19
mRNA CAPN2 GDSC1000 AAC -0.34 7e-17
mRNA GPC2 GDSC1000 AAC 0.29 1e-15
mRNA AHNAK GDSC1000 AAC -0.29 1e-15
mRNA TIMP1 GDSC1000 AAC -0.27 9e-15
mRNA ZNF232 GDSC1000 AAC 0.24 1e-14
mRNA S100A6 GDSC1000 AAC -0.28 3e-14
mRNA CD79A GDSC1000 AAC 0.29 6e-14
mRNA MYOF GDSC1000 AAC -0.32 7e-14
mRNA ZNF682 GDSC1000 AAC 0.24 2e-13
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