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GSK461364

Synonyms

SourcesNames Used
GRAY, CTRPv2GSK461364
PharmacoGx GSK461364

External IDs

DatabaseIdentifier
Smiles: CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N
Inchikey: ZHJGWYRLJUCMRT-QGZVFWFLSA-N
Pubchem: 15983966

Annotated Targets

PLK1

Cell lines tested with GSK461364

850 cell lines have been tested with this compound, using data from 2 dataset(s).
UACC-893 breast GRAY7
MDA-MB-468 breast GRAY, CTRPv27
MDA-MB-436 breast GRAY7
HCC2185 breast GRAY6
HCC1954 breast GRAY, CTRPv26
HCC1395 breast GRAY, CTRPv26
MCF7 breast GRAY, CTRPv25
ZR-75-1 breast GRAY, CTRPv25
UACC-812 breast GRAY5
MDA-MB-361 breast GRAY, CTRPv25
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Top molecular features associated with response to GSK461364


Feature TypeStandardized
Nominal ANOVA
mRNA TAF5 CTRPv2 AAC 0.31 2e-19
mRNA HNRNPA1 CTRPv2 AAC 0.3 1e-17
mRNA ARHGAP19 CTRPv2 AAC 0.32 7e-17
mRNA CPSF6 CTRPv2 AAC 0.28 6e-16
mRNA ORC1 CTRPv2 AAC 0.28 9e-16
mRNA CD63 CTRPv2 AAC -0.3 3e-15
mRNA SAFB CTRPv2 AAC 0.28 4e-15
mRNA KHDRBS1 CTRPv2 AAC 0.25 6e-15
mRNA ARHGAP19-SLIT1 CTRPv2 AAC 0.29 6e-15
mRNA PEA15 CTRPv2 AAC -0.28 7e-15
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