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GSK2126458

Synonyms

SourcesNames Used
GDSC1000, GRAYGSK2126458
PharmacoGx GSK2126458

External IDs

DatabaseIdentifier
Smiles: COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F
Inchikey: CGBJSGAELGCMKE-UHFFFAOYSA-N
Pubchem: 25167777

Annotated Targets

MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG

Cell lines tested with GSK2126458

1003 cell lines have been tested with this compound, using data from 2 dataset(s).
UACC-812 breast GDSC1000, GRAY5
HCC1954 breast GDSC1000, GRAY5
MDA-MB-453 breast GDSC1000, GRAY4
Hs-578-T breast GDSC1000, GRAY4
HCC38 breast GDSC1000, GRAY4
MDA-MB-361 breast GDSC1000, GRAY4
HCC1419 breast GDSC1000, GRAY4
HCC1187 breast GDSC1000, GRAY4
BT-20 breast GDSC1000, GRAY4
HCC3153 breast GRAY3
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Top molecular features associated with response to GSK2126458


Feature TypeStandardized
Nominal ANOVA
mRNA S100A6 GDSC1000 AAC -0.22 3e-09
mRNA MDFI GDSC1000 AAC 0.19 3e-08
mRNA NQO1 GDSC1000 AAC -0.22 5e-08
mRNA EPC1 GDSC1000 AAC 0.19 7e-08
mRNA MEX3A GDSC1000 AAC 0.2 7e-08
mRNA ARID4B GDSC1000 AAC 0.18 1e-07
mRNA NCKAP1L GDSC1000 AAC 0.28 1e-07
mRNA GNG12 GDSC1000 AAC -0.24 3e-07
mRNA STPG1 GDSC1000 AAC -0.16 3e-07
mRNA NDFIP1 GDSC1000 AAC -0.16 3e-07
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