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GSK1120212

Synonyms

SourcesNames Used
GDSC1000Trametinib
GRAYGSK1120212
CTRPv2trametinib
PharmacoGx GSK1120212

External IDs

DatabaseIdentifier
Smiles: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5
Inchikey: LIRYPHYGHXZJBZ-UHFFFAOYSA-N
Pubchem: 11707110

Cell lines tested with GSK1120212

1150 cell lines have been tested with this compound, using data from 3 dataset(s).
MDA-MB-468 breast GDSC1000, GRAY, CTRPv29
HCC2185 breast GRAY8
MDA-MB-361 breast GDSC1000, GRAY, CTRPv28
MDA-MB-436 breast GDSC1000, GRAY7
SUM 159PT breast GRAY6
BT-549 breast GDSC1000, GRAY, CTRPv26
HCC38 breast GDSC1000, GRAY, CTRPv26
HCC1395 breast GDSC1000, GRAY6
HCC1954 breast GDSC1000, GRAY6
Hs-578-T breast GDSC1000, GRAY, CTRPv26
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Top molecular features associated with response to GSK1120212


Feature TypeStandardized
Nominal ANOVA
mRNA SPRY2 CTRPv2 AAC 0.44 4e-18
mRNA SPRY4 CTRPv2 AAC 0.35 3e-12
mRNA LYST CTRPv2 AAC 0.36 3e-12
mRNA SFXN3 CTRPv2 AAC 0.34 5e-11
mRNA BCL7A CTRPv2 AAC -0.34 4e-10
mRNA SH3TC2 CTRPv2 AAC 0.36 6e-10
mRNA PHLDA2 CTRPv2 AAC 0.32 7e-10
mRNA ZFP36L2 CTRPv2 AAC 0.31 1e-09
mRNA WDR76 CTRPv2 AAC -0.32 1e-09
mRNA PHLDA3 CTRPv2 AAC 0.33 2e-09
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