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AP-24534

Synonyms

SourcesNames Used
GDSC1000AP-24534
FIMMPonatinib
PharmacoGx AP-24534

External IDs

DatabaseIdentifier
Smiles: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Inchikey: PHXJVRSECIGDHY-UHFFFAOYSA-N
Pubchem: 24826799

Cell lines tested with AP-24534

948 cell lines have been tested with this compound, using data from 2 dataset(s).
HCC1599 breast GDSC1000, FIMM2
MDA-MB-231 breast GDSC1000, FIMM2
DU-4475 breast GDSC1000, FIMM2
MFM-223 breast GDSC1000, FIMM2
CAL-148 breast GDSC1000, FIMM2
MCF7 breast GDSC1000, FIMM2
HCC1937 breast GDSC1000, FIMM2
ML-2 haematopoietic and lymphoid tissue GDSC1000, FIMM2
SIG-M5 haematopoietic and lymphoid tissue GDSC1000, FIMM2
Hs-578-T breast GDSC1000, FIMM2
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Top molecular features associated with response to AP-24534


Feature TypeStandardized
Nominal ANOVA
mRNA PRSS57 GDSC1000 AAC 0.42 8e-34
mRNA LYL1 GDSC1000 AAC 0.41 6e-19
mRNA ST8SIA6 GDSC1000 AAC 0.28 1e-18
mRNA SIGLEC6 GDSC1000 AAC 0.28 2e-18
mRNA APOL4 GDSC1000 AAC 0.3 3e-18
mRNA CFAP161 GDSC1000 AAC 0.27 8e-17
mRNA SIGLEC12 GDSC1000 AAC 0.28 3e-16
mRNA OSM GDSC1000 AAC 0.28 1e-14
mRNA LMO2 GDSC1000 AAC 0.27 1e-13
mRNA GBGT1 GDSC1000 AAC 0.24 8e-13
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