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GDC-0449

Synonyms

SourcesNames Used
GDSC1000GDC0449
FIMMVismodegib
PharmacoGx GDC-0449

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem: 24776445

Cell lines tested with GDC-0449

904 cell lines have been tested with this compound, using data from 2 dataset(s).
MV-4-11 haematopoietic and lymphoid tissue GDSC1000, FIMM2
CCRF-CEM haematopoietic and lymphoid tissue GDSC1000, FIMM2
MDA-MB-453 breast GDSC1000, FIMM2
MFM-223 breast GDSC1000, FIMM2
ML-2 haematopoietic and lymphoid tissue GDSC1000, FIMM2
THP-1 haematopoietic and lymphoid tissue GDSC1000, FIMM2
RPMI-8226 haematopoietic and lymphoid tissue GDSC1000, FIMM2
RMG-I ovary GDSC1000, FIMM2
OV-90 ovary GDSC1000, FIMM2
NOMO-1 haematopoietic and lymphoid tissue GDSC1000, FIMM2
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Top molecular features associated with response to GDC-0449


Feature TypeStandardized
Nominal ANOVA
mRNA GUCA2B GDSC1000 AAC 0.21 2e-09
mRNA GPAM GDSC1000 AAC 0.17 6e-06
mRNA UGT2B10 GDSC1000 AAC 0.17 9e-06
mRNA ZNF275 GDSC1000 AAC -0.17 1e-05
mRNA RRP8 GDSC1000 AAC -0.17 2e-05
mRNA ASPA GDSC1000 AAC 0.16 2e-05
mRNA PNPT1 GDSC1000 AAC 0.15 2e-05
mRNA CBLN4 GDSC1000 AAC 0.14 3e-05
mRNA RAB1B GDSC1000 AAC -0.15 5e-05
mRNA DCP2 GDSC1000 AAC 0.18 6e-05
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