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AMG-706

Synonyms

SourcesNames Used
GDSC1000AMG-706
FIMMMotesanib
PharmacoGx AMG-706

External IDs

DatabaseIdentifier
Smiles: CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
Inchikey: RAHBGWKEPAQNFF-UHFFFAOYSA-N
Pubchem: 11667893

Cell lines tested with AMG-706

898 cell lines have been tested with this compound, using data from 2 dataset(s).
HCC1143 breast GDSC1000, FIMM2
ES-2 ovary GDSC1000, FIMM2
MDA-MB-468 breast GDSC1000, FIMM2
OCI-AML2 haematopoietic and lymphoid tissue GDSC1000, FIMM2
PC-3 prostate GDSC1000, FIMM2
MDA-MB-436 breast GDSC1000, FIMM2
MONO-MAC-6 haematopoietic and lymphoid tissue GDSC1000, FIMM2
SK-OV-3 ovary GDSC1000, FIMM2
T47D breast GDSC1000, FIMM2
JHOS-2 ovary GDSC1000, FIMM2
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Top molecular features associated with response to AMG-706


Feature TypeStandardized
Nominal ANOVA
mRNA GGT5 GDSC1000 AAC 0.21 6e-10
mRNA PDGFRA GDSC1000 AAC 0.23 7e-10
mRNA ZYX GDSC1000 AAC 0.22 2e-09
mRNA CYTH4 GDSC1000 AAC 0.2 2e-07
mRNA DLK1 FIMM AAC 0.79 3e-07
mRNA CSF1R GDSC1000 AAC 0.18 5e-07
mRNA JAML GDSC1000 AAC 0.18 5e-07
mRNA CD34 FIMM AAC 0.7 2e-06
mRNA SNAI3 GDSC1000 AAC 0.16 4e-06
mRNA SLAIN1 GDSC1000 AAC -0.19 5e-06
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