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17-AAG

Synonyms

SourcesNames Used
CCLE, GDSC1000, GRAY17-AAG
FIMMTanespimycin
CTRPv2tanespimycin
PharmacoGx 17-AAG

External IDs

DatabaseIdentifier
Smiles: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
Inchikey: AYUNIORJHRXIBJ-TXHRRWQRSA-N
Pubchem: 6505803

Cell lines tested with 17-AAG

1303 cell lines have been tested with this compound, using data from 5 dataset(s).
HCC2185 breast GRAY8
HCC1419 breast GDSC1000, GRAY, CTRPv28
MDA-MB-361 breast GDSC1000, GRAY, CTRPv28
MDA-MB-468 breast CCLE, GDSC1000, GRAY, FIMM, CTRPv28
MDA-MB-453 breast CCLE, GDSC1000, GRAY, FIMM, CTRPv28
Hs-578-T breast CCLE, GDSC1000, GRAY, FIMM, CTRPv28
HCC1954 breast CCLE, GDSC1000, GRAY, CTRPv28
HCC1395 breast CCLE, GDSC1000, GRAY, CTRPv28
BT-549 breast CCLE, GDSC1000, GRAY, FIMM, CTRPv28
HCC38 breast GDSC1000, GRAY, CTRPv27
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Top molecular features associated with response to 17-AAG


Feature TypeStandardized
Nominal ANOVA
mRNA NQO1 GDSC1000 AAC 0.59 7e-50
mRNA NQO1 CCLE AAC 0.62 2e-28
mRNA ABCC3 GDSC1000 AAC 0.35 8e-21
mRNA TNFRSF1A GDSC1000 AAC 0.3 3e-18
mRNA G6PD GDSC1000 AAC 0.29 2e-17
mRNA KIF1A GDSC1000 AAC -0.31 3e-17
mRNA AVPI1 GDSC1000 AAC 0.34 4e-17
mRNA S100A11 GDSC1000 AAC 0.31 7e-17
mRNA SQSTM1 GDSC1000 AAC 0.29 2e-16
mRNA LGALS1 GDSC1000 AAC 0.28 2e-16
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