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alvocidib

Synonyms

SourcesNames Used
CTRPv2alvocidib
PharmacoGx alvocidib

External IDs

DatabaseIdentifier
Smiles: CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl
Pubchem: 5287969

Annotated Targets

CDK4, CDK2, CDK6, CDK1, CDK5, CDK7, CDK8, CDK9, EGFR, PYGM

Cell lines tested with alvocidib

440 cell lines have been tested with this compound, using data from 1 dataset(s).
2004 N/A CTRPv21
42-MG-BA central nervous system CTRPv21
647-V urinary tract CTRPv21
697 haematopoietic and lymphoid tissue CTRPv21
786-0 kidney CTRPv21
8-MG-BA central nervous system CTRPv21
A101D skin CTRPv21
A172 central nervous system CTRPv21
A204 soft tissue CTRPv21
A2058 skin CTRPv21
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Top molecular features associated with response to alvocidib


Feature TypeStandardized
Nominal ANOVA
mRNA GAS6 CTRPv2 AAC -0.33 4e-12
mRNA BCL2L1 CTRPv2 AAC -0.35 5e-11
mRNA PAMR1 CTRPv2 AAC -0.3 5e-10
mRNA FAM114A1 CTRPv2 AAC -0.35 7e-10
mRNA KRTAP1-5 CTRPv2 AAC -0.3 1e-09
mRNA GREM1 CTRPv2 AAC -0.29 2e-09
mRNA TRIM8 CTRPv2 AAC -0.3 2e-09
mRNA LRP1 CTRPv2 AAC -0.3 7e-09
mRNA HSPB6 CTRPv2 AAC -0.28 9e-09
mRNA MYOF CTRPv2 AAC -0.31 1e-08
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