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etoposide

Synonyms

SourcesNames Used
GDSC1000, GRAYEtoposide
CTRPv2etoposide
PharmacoGx etoposide

External IDs

DatabaseIdentifier
Smiles: COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)C(OC4OC5COC(C)OC5C(O)C4O)c6cc7OCOc7cc26
Inchikey: VJJPUSNTGOMMGY-MRVIYFEKSA-N
Pubchem: 36462

Annotated Targets

TOP2A, TOP2B

Cell lines tested with etoposide

1282 cell lines have been tested with this compound, using data from 3 dataset(s).
HCC1419 breast GDSC1000, GRAY, CTRPv26
HCC1428 breast GDSC1000, GRAY, CTRPv26
MDA-MB-231 breast GDSC1000, GRAY, CTRPv25
MDA-MB-157 breast GDSC1000, GRAY, CTRPv25
MDA-MB-361 breast GDSC1000, GRAY, CTRPv25
HCC1569 breast GDSC1000, GRAY, CTRPv25
BT-20 breast GDSC1000, GRAY, CTRPv25
Hs-578-T breast GDSC1000, GRAY5
MDA-MB-453 breast GDSC1000, GRAY, CTRPv24
MDA-MB-415 breast GDSC1000, GRAY4
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Top molecular features associated with response to etoposide


Feature TypeStandardized
Nominal ANOVA
mRNA SLFN11 GDSC1000 AAC 0.35 4e-21
mRNA HNRNPA1 CTRPv2 AAC 0.28 2e-16
mRNA TMPO CTRPv2 AAC 0.25 7e-16
mRNA LMNB1 CTRPv2 AAC 0.26 9e-16
mRNA SLFN11 CTRPv2 AAC 0.25 1e-15
mRNA ARHGAP19 CTRPv2 AAC 0.28 9e-15
mRNA HNRNPA1L2 CTRPv2 AAC 0.27 3e-14
mRNA TOP2A CTRPv2 AAC 0.22 1e-13
mRNA CASC3 CTRPv2 AAC 0.22 1e-13
mRNA CBX2 CTRPv2 AAC 0.25 2e-13
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