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Erlotinib

Synonyms

SourcesNames Used
CCLE, GDSC1000, GRAY, FIMM, UHNBreastErlotinib
gCSI, CTRPv2erlotinib
PharmacoGx Erlotinib

External IDs

DatabaseIdentifier
Smiles: COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
Inchikey: GTTBEUCJPZQMDZ-UHFFFAOYSA-N
Pubchem: 176871

Annotated Targets

EGFR, NR1I2, ERBB2

Cell lines tested with Erlotinib

1175 cell lines have been tested with this compound, using data from 7 dataset(s).
Hs-578-T breast CCLE, gCSI, GRAY, FIMM, CTRPv210
MDA-MB-453 breast CCLE, gCSI, GRAY, FIMM, CTRPv28
MDA-MB-231 breast gCSI, GRAY, FIMM, CTRPv2, UHNBreast7
HCC1419 breast gCSI, GRAY, CTRPv2, UHNBreast7
MDA-MB-157 breast CCLE, gCSI, GRAY, CTRPv2, UHNBreast7
HCC1954 breast CCLE, gCSI, GRAY, CTRPv27
BT-549 breast CCLE, gCSI, GRAY, FIMM, CTRPv2, UHNBreast7
BT-474 breast CCLE, GDSC1000, gCSI, GRAY, FIMM, CTRPv27
T47D breast CCLE, gCSI, GRAY, FIMM, CTRPv26
SK-BR-3 breast CCLE, gCSI, GRAY, FIMM, CTRPv26
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Top molecular features associated with response to Erlotinib


Feature TypeStandardized
Nominal ANOVA
mRNA CDH3 CCLE AAC 0.45 2e-17
mRNA EGFR CTRPv2 AAC 0.3 3e-16
mRNA PRSS8 CCLE AAC 0.42 1e-15
mRNA GJB3 CCLE AAC 0.44 3e-15
mRNA FGFBP1 CCLE AAC 0.41 1e-14
mRNA PRRG4 CCLE AAC 0.39 2e-14
mRNA GPR87 CCLE AAC 0.41 3e-14
mRNA CDS1 CCLE AAC 0.42 3e-14
mRNA OVOL2 CCLE AAC 0.42 3e-14
mRNA C1orf116 CCLE AAC 0.42 4e-14
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