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Doxorubicin

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMDoxorubicin
gCSI, CTRPv2doxorubicin
PharmacoGx Doxorubicin

External IDs

DatabaseIdentifier
Smiles: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl
Inchikey: MWWSFMDVAYGXBV-FGBJBKNOSA-N
Pubchem: 32874

Annotated Targets

TOP2A

Cell lines tested with Doxorubicin

1291 cell lines have been tested with this compound, using data from 5 dataset(s).
MDA-MB-468 breast GDSC1000, gCSI, GRAY, FIMM, CTRPv29
BT-474 breast GDSC1000, gCSI, GRAY, FIMM, CTRPv28
HCC2185 breast GRAY7
MDA-MB-361 breast GDSC1000, GRAY, CTRPv27
MDA-MB-436 breast GDSC1000, gCSI, GRAY, FIMM7
MDA-MB-453 breast GDSC1000, gCSI, GRAY, FIMM, CTRPv27
MCF7 breast GDSC1000, gCSI, GRAY, FIMM, CTRPv27
MDA-MB-231 breast GDSC1000, gCSI, GRAY, FIMM, CTRPv27
HCC1419 breast GDSC1000, gCSI, GRAY, CTRPv27
SK-BR-3 breast gCSI, GRAY, FIMM, CTRPv26
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Top molecular features associated with response to Doxorubicin


Feature TypeStandardized
Nominal ANOVA
mRNA FAM117B CTRPv2 AAC 0.24 1e-14
mRNA C1QBP gCSI AAC 0.37 2e-14
mRNA HNRNPA1 CTRPv2 AAC 0.25 5e-13
mRNA SENP3-EIF4A1 gCSI AAC 0.35 5e-13
mRNA EIF4A1 gCSI AAC 0.35 7e-13
mRNA RTFDC1 CTRPv2 AAC -0.22 1e-12
mRNA NUP133 CTRPv2 AAC 0.21 2e-12
mRNA SAFB CTRPv2 AAC 0.24 4e-12
mRNA DOT1L CTRPv2 AAC 0.25 7e-12
mRNA H3F3A CTRPv2 AAC 0.22 8e-12
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