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Dasatinib

Synonyms

SourcesNames Used
GDSC1000, FIMMDasatinib
CTRPv2dasatinib
PharmacoGx Dasatinib

External IDs

DatabaseIdentifier
Smiles: CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C
Inchikey: ZBNZXTGUTAYRHI-UHFFFAOYSA-N
Pubchem: 3062316

Annotated Targets

KIT, LCK, ABL1, ABL2, BLK, EPHA2, FGR, FRK, FYN, HCK, LYN, PDGFRB, SRC, SRMS, STAT5B, YES1

Cell lines tested with Dasatinib

1070 cell lines have been tested with this compound, using data from 3 dataset(s).
A549 lung CTRPv23
CAL-51 breast FIMM, CTRPv23
IGROV-1 ovary FIMM, CTRPv23
SIG-M5 haematopoietic and lymphoid tissue GDSC1000, FIMM, CTRPv23
MV-4-11 haematopoietic and lymphoid tissue GDSC1000, FIMM, CTRPv23
P3HR-1 haematopoietic and lymphoid tissue GDSC1000, CTRPv23
DU-4475 breast GDSC1000, FIMM, CTRPv23
NCI-H1869 lung GDSC1000, CTRPv23
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv23
GDM-1 haematopoietic and lymphoid tissue GDSC1000, FIMM, CTRPv23
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Top molecular features associated with response to Dasatinib


Feature TypeStandardized
Nominal ANOVA
mRNA ITGB1 CTRPv2 AAC 0.32 1e-14
mRNA PIM1 CTRPv2 AAC 0.27 2e-13
mRNA C1orf43 CTRPv2 AAC -0.25 1e-11
mRNA RRAS2 CTRPv2 AAC 0.26 3e-11
mRNA ALDH9A1 CTRPv2 AAC -0.24 4e-11
mRNA SPIRE2 CTRPv2 AAC -0.26 2e-10
mRNA UBE2Q1 CTRPv2 AAC -0.23 2e-10
mRNA NDUFB11 CTRPv2 AAC -0.23 2e-10
mRNA MRPS14 CTRPv2 AAC -0.23 3e-10
mRNA EFR3B CTRPv2 AAC -0.24 4e-10
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