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CI-1040

Synonyms

SourcesNames Used
GDSC1000CI-1040
PharmacoGx CI-1040

External IDs

DatabaseIdentifier
Smiles: C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
Inchikey: GFMMXOIFOQCCGU-UHFFFAOYSA-N
Pubchem: 6918454

Annotated Targets

MAP2K2, MAP2K1

Cell lines tested with CI-1040

884 cell lines have been tested with this compound, using data from 1 dataset(s).
H290 pleura GDSC10001
NCI-H69 lung GDSC10001
SK-MEL-5 skin GDSC10001
K2 thyroid GDSC10001
DJM-1 skin GDSC10001
NCI-H2405 lung GDSC10001
OCI-LY-19 haematopoietic and lymphoid tissue GDSC10001
NCI-H2291 lung GDSC10001
JHH-4 liver GDSC10001
NCI-H720 lung GDSC10001
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Tissues tested with CI-1040

34 tissues have been tested with this compound, using data from 1 dataset(s).
haematopoietic and lymphoid tissueGDSC1000165
lungGDSC1000147
central nervous systemGDSC100053
skinGDSC100050
large intestineGDSC100047
breastGDSC100046
ovaryGDSC100045
boneGDSC100037
oesophagusGDSC100034
autonomic gangliaGDSC100029
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Top molecular features associated with response to CI-1040


Feature TypeStandardized
Nominal ANOVA
mRNA SPRY2 GDSC1000 AAC 0.3 8e-17
mRNA TIMP1 GDSC1000 AAC 0.28 2e-15
mRNA LYZ GDSC1000 AAC 0.27 7e-15
mRNA B3GNTL1 GDSC1000 AAC 0.25 1e-14
mRNA MYO1F GDSC1000 AAC 0.27 5e-14
mRNA LGALS1 GDSC1000 AAC 0.27 6e-14
mRNA RAB39B GDSC1000 AAC -0.28 7e-14
mRNA LTBR GDSC1000 AAC 0.31 2e-13
mRNA TNFRSF1A GDSC1000 AAC 0.26 2e-13
mRNA GKAP1 GDSC1000 AAC -0.25 3e-13
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