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CHIR-99021

Synonyms

SourcesNames Used
GDSC1000, CTRPv2CHIR-99021
PharmacoGx CHIR-99021

External IDs

DatabaseIdentifier
Smiles: CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
Inchikey: AQGNHMOJWBZFQQ-UHFFFAOYSA-N
Pubchem: 9956119

Annotated Targets

CDK1, GSK3A, GSK3B, MAPK1

Cell lines tested with CHIR-99021

1312 cell lines have been tested with this compound, using data from 2 dataset(s).
A549 lung GDSC1000, CTRPv24
NCI-H1869 lung GDSC1000, CTRPv24
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv24
NCI-H460 lung GDSC1000, CTRPv24
DU-145 prostate GDSC1000, CTRPv24
NCI-H1299 lung GDSC1000, CTRPv24
CCF-STTG1 central nervous system GDSC1000, CTRPv24
OAW-28 ovary GDSC1000, CTRPv24
AsPC-1 pancreas GDSC1000, CTRPv24
HeLa cervix GDSC1000, CTRPv24
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Top molecular features associated with response to CHIR-99021


Feature TypeStandardized
Nominal ANOVA
mRNA CYR61 GDSC1000 AAC 0.31 3e-12
mRNA GPX8 GDSC1000 AAC 0.3 9e-12
mRNA TNFRSF12A GDSC1000 AAC 0.31 2e-11
mRNA ELK3 GDSC1000 AAC 0.22 3e-11
mRNA TOP2B CTRPv2 AAC 0.24 3e-11
mRNA WWTR1 GDSC1000 AAC 0.29 3e-11
mRNA HMGA2 GDSC1000 AAC 0.22 4e-11
mRNA MYOF GDSC1000 AAC 0.28 5e-11
mRNA RAG2 CTRPv2 AAC 0.21 2e-10
mRNA PLIN3 GDSC1000 AAC 0.21 3e-10
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