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SourcesNames Used
PharmacoGx AEW541

External IDs

Smiles: C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
Pubchem: 11476171

Annotated Targets


Cell lines tested with AEW541

503 cell lines have been tested with this compound, using data from 1 dataset(s).
TYK-nu ovary CCLE1
TT2609-C02 thyroid CCLE1
TOV-21G ovary CCLE1
TOV-112D ovary CCLE1
Toledo haematopoietic and lymphoid tissue CCLE1
TEN endometrium CCLE1
TE-9 oesophagus CCLE1
TE 617.T soft tissue CCLE1
TE-5 oesophagus CCLE1
TE-15 oesophagus CCLE1
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Top molecular features associated with response to AEW541

Feature TypeStandardized
Nominal ANOVA
mRNA AMPD1 CCLE AAC 0.31 1e-11
mRNA IGF1R CCLE AAC 0.32 1e-11
mRNA TP53INP1 CCLE AAC 0.29 7e-10
mRNA GPRC5D CCLE AAC 0.28 7e-10
mRNA DEK CCLE AAC -0.27 1e-09
mRNA NLRC3 CCLE AAC -0.42 6e-09
mRNA PTPRC CCLE AAC -0.42 2e-08
mRNA SASH3 CCLE AAC -0.4 2e-08
mRNA SWT1 CCLE AAC 0.26 2e-08
mRNA C1orf56 CCLE AAC 0.26 3e-08
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