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ABT-263

Synonyms

SourcesNames Used
GDSC1000, FIMMNavitoclax
CTRPv2navitoclax
PharmacoGx ABT-263

External IDs

DatabaseIdentifier
Smiles: CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey: JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem: 24978538

Annotated Targets

BCL2, BCL2L2, BAD

Cell lines tested with ABT-263

1251 cell lines have been tested with this compound, using data from 3 dataset(s).
IGROV-1 ovary GDSC1000, FIMM, CTRPv24
A549 lung GDSC1000, CTRPv24
CAL-51 breast GDSC1000, FIMM, CTRPv24
GDM-1 haematopoietic and lymphoid tissue GDSC1000, FIMM, CTRPv23
OV-90 ovary GDSC1000, FIMM, CTRPv23
NOMO-1 haematopoietic and lymphoid tissue GDSC1000, FIMM, CTRPv23
LOXIMVI haematopoietic and lymphoid tissue GDSC1000, CTRPv23
Hs-578-T breast GDSC1000, FIMM, CTRPv23
NCI-H460 lung GDSC1000, CTRPv23
CCF-STTG1 central nervous system GDSC1000, CTRPv23
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Top molecular features associated with response to ABT-263


Feature TypeStandardized
Nominal ANOVA
mRNA ARHGAP33 CTRPv2 AAC 0.32 2e-18
mRNA YPEL1 CTRPv2 AAC 0.32 2e-18
mRNA ZNF606 CTRPv2 AAC 0.3 1e-16
mRNA ZFP14 CTRPv2 AAC 0.29 6e-16
mRNA DNMT3A CTRPv2 AAC 0.3 1e-15
mRNA ZNF737 CTRPv2 AAC 0.28 1e-14
mRNA GRIK5 CTRPv2 AAC 0.27 3e-14
mRNA ZNF8 CTRPv2 AAC 0.29 6e-14
mRNA ZNF71 CTRPv2 AAC 0.29 7e-14
mRNA SOX4 CTRPv2 AAC 0.26 9e-14
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